BIOCHEMICAL ENGINEERING Course Outline :
Lect. hours
Topic :
3.0h :
 "Principles
of "biotechnology" (intro – summary as required)
Microbial cultures and process conditions, parameters
and requirements, bio-energetics
Key metabolic activities and pathways, product
formation
4.5h :
Bioreactor
design and operation: CSTR concept and microbial growth kinetics
Bioreactor instrumentation: On-line probes and off-line
analyses
6.0h :
Bioreactor
performance modeling and process simulation:
Energy and mass balances, yield expressions for
bio-systems
Mathematical models for the bioreactor system and
its
performance simulation
(QUIZZ likely here)
4.5h :
Bioreactor
aeration and agitation:
Oxygen transfer and kLa
Bioreactor scale-up and scale-down criteria
3.0h :
Dimensionless
parameters, bioreactor mixing
Principles of bioreactor scale-up
6.0h :
Up-stream
operations:
Sterilization techniques
Sterilization of liquid media and hardware
Sterilization of air
(QUIZZ likely here)
9h :
Down-stream
processing: Volume reduction, product recovery & purification 6h
Solid-liquid separation by filtration (and centrifugation)
Sorption processes and Chromatography
(The topics might not necessarily be covered exactly
in the sequence as listed here and the lecture-hours are approximate)
Course
Requirements and Rules: 
The course is a compulsory advanced undergraduate course
for Chemical Engineers. Pre-requisites are required as listed in
the University Calendar.
Knowledge of principles is assumed as taught in the required
pre-requisite courses.
The class meets Tuesdays and Thursdays
from 10:00 - 11:30h in the WONG Chemical Engineering
Bldg., Rm. 1020, starting on September 6, 2001.
It is recommended that students follow the "Lecture Notes"
during the lectures and take their own notes supplementing this condensed
written material. There will be only few additional materials
handed out. There may be some special assignments/projects
given out during the semester (10-15% of the final mark).
While standard assignments are normally NOT marked, their
material may be examined.
The final mark will be based on two quizzes (30-35%)and
the Final Exam (55%).
Course
Mark :
2001 course session :
The final mark is composed from suggested Term Exercises:
-
2 Quizzes 30-35%
-
Final Exam 55%
-
Project Assignment: normally 10-15%, (this remains
flexible)
Study
Material :
Additional recommended reading material :
Bailey,
J.E. and D.F. Ollis. 1986. Biochemical Engineering Fundamentals,
2nd ed. McGraw-Hill, New York.
Aiba, S., A.E. Humphrey and N.F. Millis. 1965. Biochemical Engineering.
Academic Press, N.Y
(Note: Sterilization is NOT well covered
in the 1977 2nd ed.)
Schedule
2001 :
DATE
TOPIC (just) COVERED :
Sep. 6 (Th) Course Introduction
- "Biotechnology"
Sep. 11(Tu) Microbial culture requirements
Sep. 13(Th) Batch culture, growth rates and
other parameters
Sep. 18(Tu) Continuous-flow culture:
CSTR and other modes
Sep. 20(Th) Continuous-flow culture modifications
Sep. 25(Tu) Bioreactor modeling: Discussion
of the Project
Sep. 27(Th)
Oct. 2 (Tu)
Oct. 4 (Th)
Oct. 9 (Tu)
Oct. 11(Th)
Oct. 16(Tu)
Oct. 18(Th)
Oct. 23(Tu)
Oct. 25(Th)
Oct. 30(Tu)
Nov. 1 (Th)
Nov. 6(Tu)
Nov. 8 (Th)
Nov. 13(Tu)
Nov. 15(Th)
Nov. 20(Tu)
Nov. 22(Th)
Nov. 27(Tu)
Nov. 29(Th)
Dec. 4 (Tu)
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